As for the visitors, while Atletico Madrid might have managed to pick up a 1-0 win against Liverpool at the Wanda Metropolitano a fortnight ago and extend their unbeaten run to six matches on the bounce, the Spanish outfit have struggled to make much of a statement this year. Playing out back-to-back stalemates against Sevilla and rock-bottom Espanyol since opening March, Diego Simeone s men find themselves sat down in fifth in the La Liga standings and have a growing reputation for their issues on the road. Remarkably, along with crashing out of the Copa del Rey thanks to an embarrassing 2-1 defeat against lower league Cultural Leonesa, Los Colchoneros have now failed to win any of their last six away fixtures across all formats, a run that stems back to the 9th of January. With the pressure on Simeone the highest it has been during his tenure in the capital, it should also be noted that Atletico have been hit with back-to-back Champions League defeats on foreign soil and have recorded just a sole European away victory since September 2018.
Team News
After missing the first leg, attacking starlet Joao Felix is likely to return to Simeone s starting XI in midweek with it appearing that former Chelsea misfit Alvaro Morata will face a late fitness test.
There also remain doubts over full-back Kieran Trippier who appeared to pick up a minor knock in their 2-2 draw with Sevilla.
Key Factors to Consider
When the two sides faced off in the first-leg a fortnight ago, Atletico Madrid picked up a 1-0 win at the Wanda Metropolitano.
Despite losing three of their last five contests, Liverpool have won their previous 11 consecutive matches at Anfield across all competitions.
Atletico Madrid have failed to win any of their last six away fixtures across all competitions.
The Premier League outfit have failed to record a clean sheet in their last five appearances.
Along with back-to-back Champions League defeats on the road, Atletico have landed just a single European victory on foreign soil since September 2018.
Conclusion
While Liverpool might have managed to pick up a 2-1 win over Bournemouth on Saturday lunchtime, Jurgen Klopp will know that his side must make some vast improvements if they re to pull off another European comeback at Anfield. Still showing some worrying issues at the back and failing to record a clean sheet in their last five matches on the bounce, a struggling Atletico should be looking to cause an upset in midweek. While Wednesday s guests might be in the midst of a woeful run of form while outside of the Spanish capital, we re backing Los Colchoneros to breach Liverpool s defence at some point in what could be a lively contest at Anfield.
Verdict: Atletico Madrid to score anytime
Best Odds: